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Curious about which THC cannabinoid is stronger between THC-O & delta-8? You already know they’re strong, but do you want to know which is actually stronger?

It’s time to settle this debate once and for all. Below, we’ll be comparing potency, effects, therapeutic benefits, legality, availability; anything and everything.

While we’re at it, we also compared the top online sellers and narrowed it down to the best five.

We’ll let you weigh the pros and cons and decide for yourself which company works best for your individual needs. But if you want our opinion, we’d recommend Exhale Wellness as the overall best.

Without further ado, let’s get ready to rumble!

What Is THC-O?

THC-O, or THC-O acetate, is a potent form of THC derived from cannabis plants. What makes it different is the process it goes through during extraction. 

In a nutshell, THC-O is like a turbocharged version of THC, with the acetylation process giving it an edge in potency and duration. 

As more research unfolds, it’s essential to use THC-O responsibly and be mindful of its potential strength.

Did You Know

Extraction and Properties

Instead of the usual THC extraction, THC-O undergoes acetylation, where an acetyl group is added to the THC molecule. This tweak changes the chemical structure, making THC-O potentially stronger and more intense.

People say THC-O hits harder than regular THC. The acetylation process is thought to make it more potent, so you might need less to feel the effects. 

Keep in mind that individual experiences may vary, but you can expect a more intense high and effects that stick around longer than those of normal THC. 

What Is Delta-8?

Delta-8, used in delta-8 carts, stands out as a cannabinoid with moderate psychoactive effects, offering a nuanced and clear-headed high. 

Its extraction from hemp, legal status in some regions, and diverse product availability contribute to its growing popularity as an alternative to classic THC. 

Sources and Effects

Delta-8 is a cannabinoid gaining attention for its unique properties and effects. It is a naturally occurring compound found in cannabis plants, albeit in trace amounts. 

Delta-8 is extracted from a hemp plant or a cannabis plant through various methods. It can be synthesized directly from CBD or extracted from the cannabis plant material using solvents. The extracted delta-8 is then refined to achieve the desired purity.

While delta-9 THC is the more well-known psychoactive component, delta-8 offers a milder alternative, creating a buzz without the intensity often associated with its counterpart.

Users often describe the high as clear-headed and functional, without the overwhelming intensity commonly associated with THC. 

Similarities Between Delta-8 THC and THC-O

The shared origins of THC-O & delta-8 in the cannabis plant, their interaction with the endocannabinoid system, uplifting effects, and legal complexities underscore the common ground between these hemp-derived cannabinoids. 


THC-O & delta-8 THC share a common origin — they are derived from the cannabis plant.

Whether obtained from hemp plants or marijuana, these cannabinoids belong to the same botanical family. 

However, their paths diverge during the extraction and production processes, leading to distinct chemical compositions and effects.

Interaction in the Body

Once consumed, THC-O & delta-8 interact with the endocannabinoid system in the human body and may give users potential benefits, and psychedelic effects and affect the nervous system (generally positively) in various forms.

This system plays a crucial role in regulating various physiological processes, such as mood, appetite, and sleep. 

Uplifting Effects

Users commonly report uplifting effects from THC-O and delta-8 THC. The sensations of euphoria, relaxation, and altered perception are shared experiences that contribute to the appeal of these cannabinoids. 


The legal status of THC O & delta-8 THC is a dynamic and evolving landscape. Both face regulatory scrutiny, with varying degrees of legality depending on regional laws. 

Side Effects

Similar to normal THC, THC O & delta-8 can potentially produce side effects. These health risks may include dry mouth, red eyes, impaired coordination, and altered cognitive function. 


While indeed similar, THC O and delta-8 THC also have plenty of differences between them. When it comes to potency, effects, and production, we can clearly see that THC-o is, for most consumers, at least, stronger.


One of the most notable differences between THC-O and delta-8 lies in their reported potency levels. THC-O is often touted as being more potent than delta-8

Users claim that even in smaller doses, THC-O can deliver a stronger and longer-lasting high compared to delta-8. 


The psychoactive effects of THC-O and delta-8 THC differ in terms of intensity and duration. 

Users report that THC-O induces a more intense and immersive high, with effects that can last significantly longer than those of delta-8. 

Delta-8, in contrast, is often described as providing a more moderate and clear-headed experience. 


The processes involved in the production of THC O and delta-8 THC contribute significantly to their divergent effects.  THC-O undergoes an acetylation process during extraction, altering the THC molecule’s chemical structure. 

This modification is believed to be responsible for the reported increase in potency. Delta-8, on the other hand, is typically extracted through various methods, such as distillation or isolation from CBD. 

The absence of acetylation contributes to delta-8’s distinct effects and perceived milder potency.

Comparative Analysis

The comparative analysis involves a nuanced examination of potency, psychoactive properties, and legal considerations.

Differences Between Delta 8 and THC-O

Potency and Strength

While concrete scientific studies are still catching up, anecdotal evidence suggests that THC-O is perceived as more potent than delta-8. 

Right now, there’s a consensus that THC-O is around six times more potent than delta-8, but there is no solid evidence or scientific study to back up that claim.

Reports from users indicate that even small amounts of THC-O can deliver a notably stronger and more enduring high than delta-8.  

However, it’s crucial to approach anecdotal evidence with caution, as individual responses can vary, and more research is needed to substantiate these claims.

Psychoactive Properties

THC-O is frequently associated with a more intense and immersive high, leading users to describe its effects as profound and potent.  In contrast, delta-8 is often characterized by a more moderate and clear-headed experience.

In the realm of semi-synthetic cannabinoids like THC-O-acetate (THC-Oac), there is a growing interest fueled by claims of psychedelic effects.  The first study to explore this assertion involved the development of an online survey for THC-Oac consumers. [1]

Participants reported a low to moderate level of cognitive distortions and few visuals or hallucinations, falling below the threshold for a complete mystical experience on all dimensions of the Mystical Experience Questionnaire (MEQ). 

Interestingly, users with prior experience with classic psychedelics scored lower on MEQ dimensions, and a significant portion stated that using THC-Oac was not a psychedelic experience. 

So, from a psychoactive standpoint, in the battle of THC-O vs delta-8, delta-8, although less strong than delta-9, has more chances of giving users a psychoactive experience.

Legality and Availability

Almost everywhere in the world, THC-O is considered illegal and a controlled substance. Cannabis laws tend to change frequently, so it might not be the same situation in the future, and THC-O’s legal status might change.

However, delta-8 THC is federally legal and legal in most countries that generally have a good outlook on cannabis use – such as some parts of Asia, Europe, and the US.

Both THC-O and delta-8 have gained popularity, leading to increased availability in the market. However, this availability can be influenced by legal restrictions. 

Users should explore reputable sources and adhere to legal guidelines when seeking products containing these cannabinoids.

Legality of THC-O vs Delta-8

The 2018 Farm Bill legalized hemp plants and their derivatives, including those with less than 0.3 percent delta-9 THC. 

In May 2022, the Ninth Circuit Court of Appeals determined that delta-8 THC aligns with the Farm Bill definition of a federally legal hemp plant product. 

This interpretation led many manufacturers to believe that THC-O also falls within the legal framework. 

However, in February 2023, the Drug Enforcement Administration (DEA) issued a letter to cannabis plants attorney Rod Kight asserting that THC-O is considered a federally controlled Schedule 1 drug. 

This declaration implies that the DEA could take enforcement actions against THC-O producers or sellers at any time, potentially involving product seizures, employee arrests, and charges under the Controlled Substances Act. 

THC-O & Delta-8: What’s the Best Dosage?

There’s no one-size-fits-all when it comes to doses for THC-O or delta-8. It depends on several factors like experience, age, general health, and more. 

So the best course of action for either of them is to:

  • Start low and go slow
  • Consider individual sensitivity & tolerance
  • Observe effects
  • Make gradual adjustments
  • Avoid overconsumption
  • Stay informed

Can You Mix THC-O and Delta-8?

The combination of THC-O and delta-8 can potentially lead to intensified psychoactive effects, and it’s important to approach such combinations with caution. 

Both THC-O & delta-8 are cannabinoids that interact with the endocannabinoid system, and their effects can be addictive. 

The interaction of THC-O and delta-8 in the body is not well-researched, and there is limited scientific data on the potential synergistic or adverse effects of combining these cannabinoids.

Considering the legal status of THC-O and delta-8, combining these cannabinoids may lead to legal issues. 

Taking all these factors into consideration, the answer is that you should probably not mix THC-O and delta-8, as there are not enough studies on the matter, so it’s not considered safe.

Safety Considerations

Safety considerations are paramount when using cannabinoids like THC-O and delta-8. 

While these compounds are gaining popularity, it’s essential to approach their consumption with caution and awareness of potential risks. 

Here are key safety considerations for using THC-O or delta-8:

  • Start with low dosages
  • Understand the legal landscape
  • Avoid combining with other substances
  • Seek professional guidance
  • Be aware of potential side effects
  • Avoid driving or operating machinery
  • Limit frequency of use
  • Purchase from reputable sources
  • Stay hydrated and well-nourished
  • Know your limits

Which Is Right for You?

Choosing between THC-O and delta-8 depends on individual preferences, tolerance, and desired effects. 

Here are some considerations to help you decide which may be right for you:

Potency and Intensity

Known for its reported higher potency and potentially more intense effects, THC-O may be suitable for experienced users seeking a robust and prolonged high.

Generally considered milder, delta-8 offers a balanced experience with less intensity than THC-O. This may be preferable for those looking for a more moderate and clear-headed high.

Tolerance and Experience

If you have a high tolerance or extensive experience with hemp-derived cannabinoids, you might appreciate the heightened effects of THC-O.

Suitable for users with varying levels of experience. If you’re new to cannabinoids or prefer a more moderate experience, delta-8 might be a better starting point.

Duration of Effects

Known for potentially longer-lasting effects, THC-O may appeal to those seeking an extended and immersive experience.

While effects vary, delta-8 generally offers a duration comparable to classic THC. It may be a more manageable option for those seeking a moderate experience.

Personal Preferences

If you’re seeking a potentially more intense experience, and legal considerations are not a hindrance, THC-O might align with your preferences.

If you prefer a milder high or want a more readily available option, delta-8 could be a better fit.


We’ll answer some of the frequently asked questions on THC-O vs delta-8 in this next section. 

Is THC-O Really Stronger Than Delta-9?

THC-O is stronger than delta-9 THC; according to users, people said they experienced a more intense and prolonged high.

Is THC-O Legal in the USA?

THC-O is illegal in the USA, the DEA considers it a federally controlled Schedule 1 drug.

Will You Fail a Drug Test for THC-O?

Yes, you can fail a drug test for THC-O, as many standard tests look for THC metabolites, which can be present after consuming THC-O.

Will THC-O vs Delta-8 THC Show Up on Drug Tests?

Yes, THC-O and delta-8 will show up on drug tests. They both have the potential to show up on drug tests, as they can produce THC metabolites similar to traditional THC. 

Final Verdict

It’s not easy to decide on a clear winner in the THC-O vs delta-8 battle, at least not in the current legal setting.

While both THC-O & delta-8 have their pluses and minuses and potential therapeutic benefits, it’s still a matter of personal preferences. Still, for now, delta-8 takes the win as it’s safer to consume legally and biologically, and more studies have been done on it.

No matter what you choose, in the end, it’s of the utmost importance that you only buy from reputable sellers. So we urge you to check out our recommended top 5 and pick the one that’s right for you, be it Exhale Wellness or another great brand from our top. Have a good one!


  1. Kruger DJ, Bone CC, Meacham MC, Klein C, Kruger JS. THC-O-Acetate: Scarce Evidence for a Psychedelic Cannabinoid. J Psychoactive Drugs. 2023 Jun 29:1-5. doi: 10.1080/02791072.2023.2230573. Epub ahead of print. PMID: 37381980.
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